Pathogenesis of odontogenic keratocyst pdf

Odontogenic keratocysts are benign lesions of the maxillomandibular region with high growth. Keratocystic odontogenic tumour of lesions treated in our clinic. The aim of this study was to discuss the aspects regarding the diagnosis, prognosis and treatment of odontogenic keratocyst tumor, through the report of two cases. The odontogenic keratocyst is an important part in the clinical features of basal cell nevus syndrome or gorlin and goltz syndrome. The orthokeratinizing odontogenic cyst is considered an unrelated entity without risk of recurrence or aggressive growth or association with nevoid basal cell carcinoma syndrome. Review of molecular pathogenesis of odontogenic keratocyst. There were 18 lesions in the posterior mandible, 3 in the anterior mandible and 6 in the posterior maxilla fig. Induced proliferation of epithelial cell rests rests of serres or malassez in the jaw region plays an important role in the pathogenesis of odontogenic cysts. Molecular alterations in odontogenic keratocysts as potential. The keratocyst odontogenic tumor has characteristics, with slow development, does not cause metastases and provides great bone destruction. Review of the molecular pathogenesis of the odontogenic.

Odontogenic keratocyst wikimili, the best wikipedia reader. The odontogenic keratocyst arises by proliferation of the residues of the dental. The term okc was first used in 1956 by philipsen12 to describe an odontogenic cyst with a keratinous epithelial lining. The odontogenic keratocyst keratocystic odontogenic tumour okc is one of the most prevalent odontogenic tumours. Keratocystic odontogenic tumour canadian dental association. Molecular analysis to demonstrate that odontogenic. The odontogenic keratocyst is a very well known odontogenic cyst. Review of the molecular pathogenesis of the odontogenic keratocyst. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. Pathogenesis and nomenclature of odontogenic carcinomas. A case report of odontogenic keratocyst in anterior. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Epithelial developmental cyst derived from enamel organ or dental lamina. Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour.

Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. The odontogenic keratocyst okc is a cystic lesion, lined by. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium.

This study was conducted on 23 and 26 cases of dc and kcot, respectively. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Comparison of components of cystic fluid in odontogenic keratocyst, dentigerous cyst, and radicular cyst type of cystsalbumin globulin total protein odontogenic keratocyst between 2 and 4 gdl between 0. In the past, odontogenic keratocysts okcs were considered to originate from the primordium of a tooth before mineralization had taken place. The odontogenic keratocyst okc is the most important of the toothderived cysts. This study was aimed to evaluate and compare the density of mast cells in dentigerous cyst dc and keratocystic odontogenic tumor kcot regarding their different clinical behavior. Regezi and others have attempted to explain the pathogenetic mechanisms of okc 7. Odontogenic cysts are largely classified based on their location, viability of the associated tooth and clinical setting the principal exception to this is the odontogenic keratocyst, which can occur in any site or setting unlike most of the other cysts, it has aggressive potential. Odontogenic keratocyst and keratocystic odontogenic tumour. The odontogenic keratocyst arises by proliferation of the residues of the dental lamina, possibly as a hamartomatous abnormality.

It most often affects the posterior mandible and most commonly presents in the third decade of life. Histopathological diagnosis of parakeratinised odontogenic keratocyst was established in all the four lesions. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. Multiple, multifocal odontogenic keratocysts in non. The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. Odontogenic keratocyst keratocystic odontogenic tumour ptch genetics. Presentation of a keratocystic odontogenic tumor with. Odontogenic keratocysts to keratocystic odontogenic tumor. Comparison of components of odontogenic cyst fluids. Calcifying odontogenic keratocyst annals of clinical case reports. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Odontogenic keratocyst okc is an odontogenic cyst and because of its ability in growth and creation tumoral lesions is placed in odontogenic tumor okt. Odontogenic keratocyst is a distinctive odontogenic cyst with a potential for aggressive behavior, local recurrence, and an association with nbccs.